Myrbetriq and Tamsulosin Hydrochloride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Mirabegron may increase the blood levels and effects of tamsulosin. This can cause blood pressure to fall excessively and heart rate to increase, especially when you rise from a sitting or lying position. The risk of other side effects such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity) may also increase. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if you develop these symptoms while using tamsulosin and they do not go away on their own or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medication affects you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with mirabegron may increase the plasma concentrations of tamsulosin. The proposed mechanism is mirabegron inhibition of tamsulosin metabolism via CYP450 2D6 and 3A4. In healthy study subjects, tamsulosin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by more than 50% when a single 0.4 mg dose of tamsulosin was administered following multiple dosing of mirabegron 100 mg daily. In contrast, mirabegron Cmax and AUC decreased by approximately 20% when a single 100 mg dose of mirabegron was administered following multiple dosing of tamsulosin 0.4 mg daily.

MANAGEMENT: No dosage adjustment is recommended when tamsulosin is coadministered with mirabegron. However, caution is advised, particularly when tamsulosin is prescribed at a dosage higher than 0.4 mg/day. The potential for increased risk of adverse effects such as postural hypotension, syncope, and priapism should be considered. Patients should be advised to avoid rising abruptly from a sitting or recumbent position, and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. Patients should also avoid driving or operating hazardous machinery until they know how the medications affect them.

Myrbetriq

Generic Name: mirabegron

Brand name: Myrbetriq

Synonyms: n.a.

What is Myrbetriq?

Tamsulosin Hydrochloride

Generic Name: tamsulosin

Brand name: Flomax

Synonyms: Tamsulosin

What is Tamsulosin Hydrochloride?