Mysoline and Ritalin LA
Determining the interaction of Mysoline and Ritalin LA and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:According to the manufacturer, methylphenidate may inhibit the metabolism of anticonvulsants including phenobarbital, phenytoin, and primidone. There have been only isolated case reports of phenytoin intoxication during coadministration with methylphenidate and none for the other anticonvulsants. Moreover, two studies found little or no effect of methylphenidate on plasma phenytoin concentrations. Thus, available evidence does not seem to support a clinically significant drug interaction. Nevertheless, it may be appropriate to monitor the pharmacologic response to these anticonvulsants more closely whenever methylphenidate (racemic) or dexmethylphenidate (the more pharmacologically active d-enantiomer) is added to or withdrawn from therapy, and the anticonvulsant dosage adjusted as necessary.
- Kupferberg HJ, Jeffery W, Hunninghake DB "Effect of methylphenidate on plasma anticonvulsant levels." Clin Pharmacol Ther 13 (1972): 201-4
- Garrettson LK, Perel JM, Dayton PG "Methylphenidate interaction with both anticonvulsants and ethyl biscoumacetate." JAMA 207 (1969): 1053-6
- "Product Information. Focalin (dexmethylphenidate)." Mikart Inc, Atlanta, GA.
- "Product Information. Ritalin (methylphenidate)." Novartis Pharmaceuticals, East Hanover, NJ.
- Ghofrani M "Possible phenytoin-methylphenidate interaction." Dev Med Child Neurol 30 (1988): 267
- Mirkin BL, Wright F "Drug interactions: effect of methylphenidate on the disposition of diphenylhydantoin in man." Neurology 21 (1971): 1123-8
Generic Name: methylphenidate
Brand name: Adhansia XR, Aptensio XR, Concerta, Cotempla XR-ODT, Jornay PM, Metadate ER, Methylin, QuilliChew ER, Quillivant XR, Relexxii, Ritalin, Ritalin LA, Metadate CD, Ritalin SR, Daytrana, Methylin ER
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Mysoline-Ritalin SR
- Mysoline-Rite Aid First Aid Epsom Salt
- Mysoline-Rite Aid Night Time Severe Cold and Cough Honey Lemon with Chamomile and White Tea Flavors
- Mysoline-Rite Aid Senna
- Mysoline-Ritodrine Oral, Intravenous
- Mysoline-Ritonavir
- Ritalin LA-Mytab Gas
- Ritalin LA-Mytelase
- Ritalin LA-Mytrex topical
- Ritalin LA-Mytussin AC
- Ritalin LA-Myxredlin
- Ritalin LA-Myxredlin Injection
Mysoline - Ritalin LA 
Mysoline - Ritalin LA 
Mysoline - Ritalin LA 
Mysoline - Ritalin LA 
Mysoline - Ritalin LA 
Mysoline - Ritalin LA 
Mysoline - Ritalin LA 
Mysoline - Ritalin LA 
Mysoline - Ritalin LA 
Mysoline - Ritalin LA 
Mysoline - Ritalin LA 
Mysoline - Ritalin LA