Nafcillin injection and Phenytoin Extended-Release Capsules
Determining the interaction of Nafcillin injection and Phenytoin Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Nafcillin may displace phenytoin from serum protein-binding sites. Plasma levels of free phenytoin may increase. Some investigators have recommended monitoring of free plasma phenytoin levels in patients who must receive both nafcillin and phenytoin.
- Dasgupta A, Dennen DA, Dean R, McLawhon RW "Displacement of phenytoin from serum protein carriers by antibiotics: studies with ceftriaxone, nafcillin, and sulfamethoxazole." Clin Chem 37 (1991): 98-100
Generic Name: nafcillin
Brand name: Unipen, Nallpen
Synonyms: Nafcillin (injection), Nafcillin
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nafcillin injection-Phenytoin Infatabs
- Nafcillin injection-Phenytoin injection
- Nafcillin injection-Phenytoin Intravenous
- Nafcillin injection-Phenytoin Oral Suspension
- Nafcillin injection-Phenytoin Sodium
- Nafcillin injection-Phenytoin Sodium, Prompt injection
- Phenytoin Extended-Release Capsules-Nafcillin Sodium
- Phenytoin Extended-Release Capsules-Nalbuphine
- Phenytoin Extended-Release Capsules-Nalbuphine Hydrochloride
- Phenytoin Extended-Release Capsules-Nalbuphine Injection
- Phenytoin Extended-Release Capsules-Naldemedine
- Phenytoin Extended-Release Capsules-Naldemedine Tosylate