Nalbuphine Hydrochloride and Orkambi

• Generic Name: nalbuphine
• Dosage Forms: n.a.
• Other Brand Names: Nubain

Relief of pain that is severe enough to require an opiate analgesic and for which alternative treatment options (e.g., nonopiate analgesics) have not been, or are not expected to be, adequate or tolerated.

Preoperative and postoperative sedation and analgesia.

Supplement to balanced surgical anesthesia.

Obstetric analgesia during labor and delivery.

In symptomatic treatment of acute pain, reserve opiate analgesics for pain resulting from severe injuries, severe medical conditions, or surgical procedures, or when nonopiate alternatives for relieving pain and restoring function are expected to be ineffective or are contraindicated. Use smallest effective dosage for shortest possible duration since long-term opiate use often begins with treatment of acute pain. Optimize concomitant use of other appropriate therapies. (See Managing Opiate Therapy for Acute Pain under Dosage and Administration.)

• Generic Name: ivacaftor / lumacaftor
• Dosage Forms: tablet, film coated
• Other Brand Names: Orkambi

Orkambi contains a combination of ivacaftor and lumacaftor. Ivacaftor and lumacaftor is used to treat cystic fibrosis in adults and children who are at least 2 years old.

Orkambi is for use only in patients with a specific gene mutation related to cystic fibrosis.

Before you take Orkambi, you may need a medical test to make sure you have this gene mutation.