Nalbuphine Hydrochloride and Paclitaxel Intravenous

• Generic Name: nalbuphine
• Dosage Forms: n.a.
• Other Brand Names: Nubain

Relief of pain that is severe enough to require an opiate analgesic and for which alternative treatment options (e.g., nonopiate analgesics) have not been, or are not expected to be, adequate or tolerated.

Preoperative and postoperative sedation and analgesia.

Supplement to balanced surgical anesthesia.

Obstetric analgesia during labor and delivery.

In symptomatic treatment of acute pain, reserve opiate analgesics for pain resulting from severe injuries, severe medical conditions, or surgical procedures, or when nonopiate alternatives for relieving pain and restoring function are expected to be ineffective or are contraindicated. Use smallest effective dosage for shortest possible duration since long-term opiate use often begins with treatment of acute pain. Optimize concomitant use of other appropriate therapies. (See Managing Opiate Therapy for Acute Pain under Dosage and Administration.)

• Generic Name: paclitaxel
• Dosage Forms: n.a.
• Other Brand Names: Onxol, Taxol

Paclitaxel injection is used to treat advanced cancer of the ovaries, breast, non-small cell lung cancer, and Kaposi sarcoma. Kaposi sarcoma is a cancer of the skin and mucous membranes that is commonly found in patients with acquired immunodeficiency syndrome (AIDS).

Paclitaxel belongs to the group of medicines called antineoplastics. It interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected, other unwanted effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern. Some effects may not occur until months or years after the medicine is used.

Before you begin treatment with paclitaxel, you and your doctor should talk about the good paclitaxel will do as well as the risks of using it.

Paclitaxel is to be administered only by or under the immediate supervision of your doctor.