Naloxegol Oxalate and Tacrolimus Extended-Release Capsules
Determining the interaction of Naloxegol Oxalate and Tacrolimus Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of P-glycoprotein (P-gp) and/or weak inhibitors of CYP450 3A4 may increase the plasma concentrations of naloxegol, which is a substrate of both the efflux transporter and the isoenzyme. When a single 25 mg dose of naloxegol was administered with a single 600 mg dose of quinidine, a potent P-gp inhibitor and weak CYP450 3A4 inhibitor, naloxegol peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 147% and 39%, respectively. These changes are not considered clinically significant; therefore, no dosage adjustments are necessary.
- "Product Information. Movantik (naloxegol)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: naloxegol
Brand name: Movantik
Synonyms: Naloxegol
Generic Name: tacrolimus
Brand name: Astagraf XL, Envarsus XR, Prograf, Hecoria
Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Naloxegol Oxalate-Tacrolimus Extended-Release Tablets
- Naloxegol Oxalate-Tacrolimus Granules for Suspension
- Naloxegol Oxalate-Tacrolimus Injection
- Naloxegol Oxalate-Tacrolimus Intravenous
- Naloxegol Oxalate-Tacrolimus oral and injection
- Naloxegol Oxalate-Tacrolimus Oral, Intravenous
- Tacrolimus Extended-Release Capsules-Naloxone
- Tacrolimus Extended-Release Capsules-Naloxone and pentazocine
- Tacrolimus Extended-Release Capsules-Naloxone Auto-Injection
- Tacrolimus Extended-Release Capsules-Naloxone Hydrochloride
- Tacrolimus Extended-Release Capsules-Naloxone Injection
- Tacrolimus Extended-Release Capsules-Naloxone nasal