Naloxone Auto-Injection and Poly-Tussin AC
Determining the interaction of Naloxone Auto-Injection and Poly-Tussin AC and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:The following interaction applies only if you are using naloxone in an injectable formulation: naloxone can reverse the effects of codeine. If you are a physically dependent patient you may experience withdrawal symptoms. This can cause nausea, vomiting, diarrhea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, and abdominal cramps. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: This warning does not apply to the naloxone component in non-injectable formulations of naloxone-containing combination medicines. Naloxone injection is an antagonist that will reverse the actions of opiates. This reversal can occur when the opiate drug is being used clinically and when it is being abused. Physically dependent patients may experience withdrawal symptoms. Abrupt postoperative opioid reversal has resulted in hypotension, ventricular tachycardia and fibrillation, pulmonary edema, cardiac arrest, encephalopathy, and death.
MANAGEMENT: Patients receiving naloxone injection should be monitored for changes in vital signs, nausea, vomiting, diarrhea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, abdominal cramps.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Narcan (naloxone)." DuPont Pharmaceuticals, Wilmington, DE.
Generic Name: naloxone
Brand name: Narcan, Evzio
Synonyms: Naloxone (nasal), Naloxone
Generic Name: brompheniramine / codeine / phenylephrine
Brand name: M-End PE, Poly-Tussin AC, TL-Hist CD
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Naloxone Auto-Injection-Poly-Tussin DM
- Naloxone Auto-Injection-Poly-Tussin EX Syrup
- Naloxone Auto-Injection-Poly-Tussin HD
- Naloxone Auto-Injection-Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Liquid)
- Naloxone Auto-Injection-Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Tablets and Capsules)
- Naloxone Auto-Injection-Poly-Vent IR
- Poly-Tussin AC-Naloxone Hydrochloride
- Poly-Tussin AC-Naloxone Injection
- Poly-Tussin AC-Naloxone nasal
- Poly-Tussin AC-Naloxone Nasal Spray
- Poly-Tussin AC-Naltrexone
- Poly-Tussin AC-Naltrexone and Bupropion