Naltrexone Intramuscular and Tracleer (Bosentan Tablets)
Determining the interaction of Naltrexone Intramuscular and Tracleer (Bosentan Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Naltrexone may cause liver problems, and using it with other medications that can also affect the liver such as bosentan may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration of naltrexone with other agents known to induce hepatotoxicity may potentiate the risk of liver injury. Naltrexone, especially in larger than recommended doses (more than 50 mg/day), has been associated with hepatocellular injury, hepatitis, and elevations in liver transaminases and bilirubin. Other potential causative or contributory etiologies identified include preexisting alcoholic liver disease, hepatitis B and/or C infection, and concomitant usage of other hepatotoxic drugs.
MANAGEMENT: The use of naltrexone with other potentially hepatotoxic agents should be avoided whenever possible (e.g., acetaminophen; alcohol; androgens and anabolic steroids; antituberculous agents; azole antifungal agents; ACE inhibitors; cyclosporine (high dosages); disulfiram; endothelin receptor antagonists; interferons; ketolide and macrolide antibiotics; kinase inhibitors; minocycline; nonsteroidal anti-inflammatory agents; nucleoside reverse transcriptase inhibitors; proteasome inhibitors; retinoids; sulfonamides; tamoxifen; thiazolidinediones; tolvaptan; vincristine; zileuton; anticonvulsants such as carbamazepine, hydantoins, felbamate, and valproic acid; lipid-lowering medications such as fenofibrate, lomitapide, mipomersen, niacin, and statins; herbals and nutritional supplements such as black cohosh, chaparral, comfrey, DHEA, kava, pennyroyal oil, and red yeast rice). Patients should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, itching, anorexia, nausea, vomiting, fatigue, malaise, right upper quadrant pain, dark urine, pale stools, and jaundice. Periodic monitoring of hepatic function is advisable.
- "Product Information. ReVia (naltrexone)." DuPont Pharmaceuticals, Wilmington, DE.
Generic Name: naltrexone
Brand name: ReVia, Depade, Vivitrol
Synonyms: Naltrexone
Generic Name: bosentan
Brand name: Tracleer
Synonyms: Tracleer
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Naltrexone Intramuscular-Tradjenta
- Naltrexone Intramuscular-Tramacet
- Naltrexone Intramuscular-Tramadol
- Naltrexone Intramuscular-Tramadol and acetaminophen
- Naltrexone Intramuscular-Tramadol Capsules
- Naltrexone Intramuscular-Tramadol ER
- Tracleer (Bosentan Tablets)-Naltrexone Tablets
- Tracleer (Bosentan Tablets)-Namenda
- Tracleer (Bosentan Tablets)-Namenda (Memantine Solution)
- Tracleer (Bosentan Tablets)-Namenda (Memantine Tablets)
- Tracleer (Bosentan Tablets)-Namenda XR
- Tracleer (Bosentan Tablets)-Namenda XR Titration Pack