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Namenda XR and Sulfatrim Pediatric

Determining the interaction of Namenda XR and Sulfatrim Pediatric and the possibility of their joint administration.

Check result:

Namenda XR <> Sulfatrim Pediatric

Relevance: 07.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Trimethoprim may increase the blood levels and effects of memantine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Trimethoprim may decrease the renal clearance of amantadine and memantine. The mechanism may be competition for organic cation transporter-2 (OCT-2)-mediated secretion in the kidney tubule of which amantadine, memantine, and trimethoprim are substrates. Trimethoprim may also inhibit OCT-2. Increased levels of amantadine and memantine may increase the risk of neurological side effects such as mental confusion, delirium, and myoclonus. Serum trimethoprim levels may also be increased.

MANAGEMENT: Caution and monitoring for nervous system side effects is recommended if trimethoprim is used with either amantadine or memantine. Patients should be advised to contact their physician if they experience nervous system side effects such as mental confusion and myoclonus.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Moellentin D, Picone C, Leadbetter E "Memantine-induced myoclonus and delirium exacerbated by trimethoprim." Ann Pharmacother 42 (2008): 449-7
Speeg KV, Leighton JA, Maldonado AL "Case report: toxic delirium in a patient taking amantadine and trimethoprim sulfamethoxazole." Am J Med Sci 298 (1989): 410-2
"Product Information. Bactrim (trimethoprim-sulfamethoxazole)." Roche Laboratories, Nutley, NJ.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Namenda XR

Generic Name: memantine

Brand name: Namenda, Namenda XR

Synonyms: n.a.

What is Namenda XR?

Sulfatrim Pediatric

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Septra, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS

Synonyms: Sulfatrim Pediatric (Oral)

What is Sulfatrim Pediatric?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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