Nateglinide and Tolazamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Nateglinide may increase the blood levels and effects of TOLAZamide. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with nateglinide may increase the plasma concentrations of drugs that are substrates of the CYP450 2C9 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 2C9 activity by nateglinide.

MANAGEMENT: Caution is advised if nateglinide must be used concomitantly with medications that undergo metabolism by CYP450 2C9, particularly those with a narrow therapeutic range. A lower initial dosage, as well as clinical and laboratory monitoring, may be appropriate for some drugs.

Nateglinide

Generic Name: nateglinide

Brand name: Starlix

Synonyms: n.a.

What is Nateglinide?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?