Navelbine and Phenobarbital Sodium
Determining the interaction of Navelbine and Phenobarbital Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using vinorelbine together with PHENobarbital. Combining these medications may reduce the blood levels and effects of vinorelbine. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 and/or P-glycoprotein may significantly decrease the plasma concentrations of vinca alkaloids, which are substrates of both the hepatic microsomal isoenzyme and intracellular efflux transporter. Pharmacokinetic data are not available.
MANAGEMENT: The use of vinca alkaloids in combination with potent CYP450 3A4 and/or P-glycoprotein inducers such as carbamazepine, dexamethasone, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, and St. John's wort should generally be avoided.
- "Product Information. Marqibo (vinCRIStine liposome)." Talon Therapeutics Inc, South San Francisco,, CA.
Generic Name: vinorelbine
Brand name: Navelbine
Synonyms: Navelbine Injection
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: Phenobarbital, PHENobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Navelbine-Phenobarbital Sodium Injection
- Navelbine-Phenobarbital Tablets
- Navelbine-Phenobarbital with Belladonna Alkaloids Elixir
- Navelbine-Phenohytro
- Navelbine-Phenohytro Elixir
- Navelbine-Phenoxybenzamine
- Phenobarbital Sodium-Navelbine Injection
- Phenobarbital Sodium-Naxen
- Phenobarbital Sodium-Nayzilam
- Phenobarbital Sodium-Nazarin HC
- Phenobarbital Sodium-Nazil Ofteno
- Phenobarbital Sodium-Nebcin