Nefazodone Hydrochloride and Zovia 1/50e

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ethinyl estradiol together with nefazodone may increase the effects of ethinyl estradiol. Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The coadministration with nefazodone may increase the plasma concentrations and pharmacologic effects of ethinyl estradiol and other estrogens. The mechanism is nefazodone inhibition of CYP450 3A4, the isoenzyme responsible for the metabolism of estrogens. In one case report, a woman taking a low-dose oral contraceptive (ethinyl estradiol-desogestrel, 20 mcg-150 mcg) developed breast tenderness, bloating, weight gain, and increased premenstrual irritability within a week following the initiation of nefazodone therapy. These symptoms were not present prior to initiating nefazodone and were described as identical to those previously experienced with oral contraceptives containing higher dosages of estrogen that she did not tolerate. In addition, her menstrual period, which had been regular for the past 18 months, was delayed by 5 days. The problems resolved after nefazodone was discontinued.

MANAGEMENT: Clinicians and patients should be aware of the potential for increased pharmacologic effects of estrogens during concomitant administration with nefazodone. Adjustments in the estrogen dosage may be required if an interaction is suspected. Alternatively, antidepressants that do not significantly interfere with CYP450 3A4 metabolism may be considered, including the SSRIs (except fluvoxamine) and venlafaxine.

Nefazodone Hydrochloride

Generic Name: nefazodone

Brand name: Serzone

Synonyms: Nefazodone

What is Nefazodone Hydrochloride?

Zovia 1/50e

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/50, Zovia 1/50E

What is Zovia 1/50e?