Drug search by name

NegGram and Videx EC

Determining the interaction of NegGram and Videx EC and the possibility of their joint administration.

Check result:

NegGram <> Videx EC

Relevance: 02.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using didanosine together with nalidixic acid may decrease the effects of nalidixic acid. Nalidixic acid should be administered at least 2 to 4 hours before or 2 to 8 hours after didanosine. Contact your doctor if your infection worsens. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor

Professional:

ADJUST DOSING INTERVAL: The coadministration with didanosine buffered tablets or pediatric oral solution may significantly reduce the oral bioavailability of quinolone antibiotics. The mechanism is reduced quinolone absorption due to chelation with metallic cations from buffering agents and antacids used in certain formulations of didanosine. In a randomized, crossover study consisting of 12 healthy volunteers, simultaneous administration of didanosine placebo tablets (buffering agents without didanosine) reduced the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of ciprofloxacin by 93% and 98%, respectively. In eight HIV-infected patients, the steady-state AUC of ciprofloxacin decreased an average of 26% when it was administered 2 hours prior to didanosine tablets. In a single subject given one dose of ciprofloxacin 2 hours after didanosine placebo tablets, ciprofloxacin AUC was reduced by more than 50%. A similar interaction is expected with other quinolones that also form chelates with divalent and trivalent metallic cations.

MANAGEMENT: Quinolone antibiotics should generally be administered at least 2 to 4 hours before or 2 to 8 hours after didanosine buffered tablets or pediatric oral solution, and patients should be monitored for potentially decreased antimicrobial efficacy during concomitant therapy. Didanosine buffered powder for oral solution, which uses a citrate-phosphate buffer, and the delayed-release capsules, which are not buffered, are not expected to cause this interaction.

References

Deppermann KM, Lode H "Fluoroquinolones: interaction profile during enteral absorption." Drugs 45 Suppl 3 (1993): 65-72
Sahai J "Avoiding the ciprofloxacin-didanosine interaction." Ann Intern Med 123 (1995): 394-5
"Product Information. Cipro (ciprofloxacin)." Bayer, West Haven, CT.
Knupp CA, Barbhaiya RH "A multiple-dose pharmacokinetic interaction study between didanosine (videx(r)) and ciprofloxacin (cipro(r)) in male subjects seropositive for HIV but asymptomatic." Biopharm Drug Dispos 18 (1997): 65-77
"Product Information. NegGram (nalidixic acid)." Sanofi Winthrop Pharmaceuticals, New York, NY.
Marchbanks CR "Drug-drug interactions with fluoroquinolones." Pharmacotherapy 13 (1993): s23-8
"Product Information. Videx (didanosine)." Bristol-Myers Squibb, Princeton, NJ.
Sahai J, Gallicano K, Oliveras L, Khaliq S, Hawley-Foss N, Garber G "Cations in the didanosine tablet reduce ciprofloxacin bioavailability." Clin Pharmacol Ther 53 (1993): 292-7
Damle BD, Mummaneni V, Kaul S, Knupp C "Lack of Effect of Simultaneously Administered Didanosine Encapsulated Enteric Bead Formulation (Videx EC) on Oral Absorption of Indinavir, Ketoconazole, or Ciprofloxacin." Antimicrob Agents Chemother 46 (2002): 385-91
Polk RE "Drug-drug interactions with ciprofloxacin and other fluoroquinolones." Am J Med 87 (1989): s76-81

NegGram

Generic Name: nalidixic acid

Brand name:

Synonyms: n.a.

What is NegGram?

Videx EC

Generic Name: didanosine

Brand name: Videx, Videx EC

Synonyms: n.a.

What is Videx EC?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions