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Nelfinavir Oral Powder and Quin-G

Determining the interaction of Nelfinavir Oral Powder and Quin-G and the possibility of their joint administration.

Check result:
Nelfinavir Oral Powder <> Quin-G
Relevance: 22.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using quiNIDine and nelfinavir is not recommended. Taking these drugs together can raise the levels of quiNIDine in your body and may affect the rhythm of your heart. Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with nelfinavir may significantly increase the plasma concentrations of amiodarone and quinidine. The proposed mechanism is nelfinavir inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of these antiarrhythmic agents. Although clinical data are lacking, the interaction could conceivably lead to serious and/or life-threatening reactions including QT interval prolongation and ventricular arrhythmias such as ventricular tachycardia and torsade de pointes.

MANAGEMENT: The use of nelfinavir with amiodarone or quinidine is considered contraindicated.

References
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  • "Product Information. Viracept (nelfinavir)." Agouron Pharma Inc, La Jolla, CA.
  • Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Nelfinavir Oral Powder

Generic Name: nelfinavir

Brand name: Viracept

Synonyms: Nelfinavir

Quin-G

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction