Nembutal and Venetoclax
Determining the interaction of Nembutal and Venetoclax and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PENTobarbital may reduce the blood levels of venetoclax, which may make the medication less effective in some cases. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of venetoclax, which is primarily metabolized by the isoenzyme. In 10 healthy volunteers, venetoclax peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 42% and 71%, respectively, when coadministered with 600 mg once daily for 13 days of rifampin, a potent CYP450 3A4 inducer. Therapeutic failure may occur. The interaction has not been studied with other, less potent inducers.
MANAGEMENT: The potential for diminished pharmacologic effects of venetoclax should be considered during coadministration with CYP450 3A4 inducers. Alternative treatments may be required if an interaction is suspected.
- "Product Information. Venclexta (venetoclax)." AbbVie US LLC, North Chicago, IL.
Generic Name: pentobarbital
Brand name: Nembutal, Nembutal Sodium
Synonyms: n.a.
Generic Name: venetoclax
Brand name: Venclexta, Venclexta Starting Pack
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nembutal-Venipuncture CPI
- Nembutal-Venipuncture PX1
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- Nembutal-Venlafaxine Extended-Release Capsules
- Venetoclax-Nembutal Sodium injection
- Venetoclax-Neo DM
- Venetoclax-Neo-Fradin
- Venetoclax-Neo-Metric
- Venetoclax-Neo-Poly-Bac
- Venetoclax-Neo-Poly-Dex