Nembutal Sodium injection and Xulane transdermal
Determining the interaction of Nembutal Sodium injection and Xulane transdermal and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PENTobarbital may decrease the effectiveness of ethinyl estradiol. If you are using low-dose contraceptives, there is an increased risk of breakthrough bleeding and unintended pregnancy during combined therapy with PENTobarbital. Alternative or additional methods of birth control should be used while taking PENTobarbital. If you take hormone replacement for menopause, notify your doctor if you have decreased efficacy of your hormones. You may notice symptoms of increased hot flashes, vaginal dryness or menstrual abnormalities. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:ADDITIONAL CONTRACEPTION RECOMMENDED: Coadministration with a barbiturate may reduce the efficacy of contraceptive hormones. There have been numerous case reports of menstrual abnormalities (e.g., breakthrough bleeding, amenorrhea, irregular menses) and unintended pregnancy occurring in women who received oral contraceptives with phenobarbital. In a study of four women treated chronically with a contraceptive pill containing 50 mcg of ethinyl estradiol, coadministration with phenobarbital (30 mg twice a day) was associated with breakthrough bleeding and a greater than 60% reduction in plasma ethinyl estradiol concentration in two of the women. The interaction stems from accelerated clearance of contraceptive hormones as well as decreased plasma concentrations of unbound (active) hormones due to induction of hepatic CYP450 enzymatic activity and enhancement of hormone-binding globulin capacity by phenobarbital. Since all barbiturates are believed to possess enzyme-inducing capabilities, the interaction should be expected with agents in the class other than phenobarbital.
MANAGEMENT: Women using hormonal contraceptives should be advised of the risk of breakthrough bleeding and unintended pregnancy during concomitant therapy with barbiturates. Alternative or additional methods of birth control should be used during and for at least one week after short-term and 4 weeks after long-term (greater than 4 weeks) barbiturate therapy. No precautions or recommendations are available for women using hormone-releasing intrauterine systems, but a significant interaction with these systems is thought to be unlikely due to their local action. Injectable progestin-only contraceptives are also thought to be unaffected by barbiturates. Input from a gynecologist or similar expert on adequate contraception, including emergency contraception, should be sought as needed.
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Generic Name: pentobarbital
Brand name: Nembutal Sodium, Nembutal
Synonyms: Nembutal Sodium (injection)
Generic Name: ethinyl estradiol / norelgestromin
Brand name: Xulane, Ortho Evra
Synonyms: Xulane (transdermal), Xulane
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nembutal Sodium injection-Xultophy
- Nembutal Sodium injection-Xultophy 100/3.6
- Nembutal Sodium injection-Xuriden
- Nembutal Sodium injection-Xylocaine
- Nembutal Sodium injection-Xylocaine (Cardiac)
- Nembutal Sodium injection-Xylocaine (Lidocaine Injection Solution (Anesthetic))
- Xulane transdermal-Neo DM
- Xulane transdermal-Neo-Fradin
- Xulane transdermal-Neo-Metric
- Xulane transdermal-Neo-Poly-Bac
- Xulane transdermal-Neo-Poly-Dex
- Xulane transdermal-Neo-Poly-Dex Eye Drops