Neomycin, Colistin, Hydrocortisone, and Thonzonium and Pyridoxine Hydrochloride

• Generic Name: colistin sulfate / hydrocortisone / neomycin / thonzonium bromide otic
• Dosage Forms: n.a.
• Other Brand Names: Coly-Mycin S, Cortisporin-TC, Coly Mycin S

• It is used to treat ear infections.

• Generic Name: pyridoxine
• Dosage Forms: n.a.
• Other Brand Names: Vitamin B6, Vitelle Nestrex, Pyridoxal 5'-Phosphate

Treatment of vitamin B6 deficiency.

Adequate intake needed to prevent vitamin B6 deficiency.

Adequate intake of pyridoxine can be accomplished through consumption of fortified ready-to-eat cereals; meals containing substantial portions of meat, fish, or poultry; white potatoes and other starchy vegetable; and noncitrus fruits.

Recommended Dietary Allowance (RDA) in adults based on a plasma pyridoxal phosphate concentration of 5 ng/mL.

Adequate intake (AI) established for infants ≤6 months of age based on observed mean vitamin B6 intake of infants fed principally human milk; AI for infants 7–12 months of age based on AI for younger infants and data in adults.

RDA for children 1–18 years of age based on data in adults.

Treatment of pyridoxine-dependent seizures.

Xanthurenic aciduria, cystathioninuria, and homocystinuria resulting from genetic abnormalities may respond to high doses of pyridoxine.

Prevent or treat neuropathy in patients receiving isoniazid. Pyridoxine prophylaxis recommended in isoniazid-treated individuals with nutritional deficiency (e.g., meat and milk-deficient diet), diabetes mellitus, HIV infection, renal failure, alcoholism, and in exclusively breast-fed infants, pregnant women, and lactating women.

Also has been used to prevent or treat neurotoxic adverse effects (e.g., peripheral neuropathy) associated with ethionamide or capecitabine.

Adjunct for treatment of acute toxicity resulting from isoniazid overdosage.

Adjunct for treatment of acute toxicity caused by mushrooms of the genus Gyromitra. Used to correct marked neurologic effects (e.g., seizures, coma) induced by methylhydrazine (produced by hydrolysis of the toxins in these mushrooms).