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Neomycin Oral Solution and Plazomicin Intravenous

Determining the interaction of Neomycin Oral Solution and Plazomicin Intravenous and the possibility of their joint administration.

Check result:

Neomycin Oral Solution <> Plazomicin Intravenous

Relevance: 07.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using neomycin together with plazomicin may increase the risk of serious side effects such as hearing loss, respiratory depression, and kidney problems. Patients who may be particularly susceptible include the elderly and those who are dehydrated or have preexisting kidney disease. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Let your doctor know immediately if you experience hearing loss, ringing in the ears, vertigo, difficulty breathing, or signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Use of more than one aminoglycoside concurrently or sequentially may increase the risk of nephrotoxicity and ototoxicity. The risk is greatest in patients with impaired renal function, those receiving high doses for prolonged periods of time, elderly patients, and dehydrated patients. Ototoxicity may occur without renal toxicity. Oral neomycin undergoes systemic absorption and has also been associated with nephrotoxicity and ototoxicity.

MANAGEMENT: The use of more than one aminoglycoside should be avoided. Patients receiving aminoglycosides should be closely monitored for development of toxicity, including renal function tests and serial, vestibular, and audiometric tests. Ototoxicity may be permanent and may not be apparent until long after therapy has been discontinued. The onset of auditory toxicity may be asymptomatic or may manifest with early symptoms such as feelings of fullness in the ear, high tone hearing loss, or tinnitus. Signs of vestibulotoxicity include ataxia, tinnitus, and vertigo.

References

Dupuis JY, Martin R, Tetrault JP "Atracurium and vecuronium interaction with gentamicin and tobramycin." Can J Anaesth 36 (1989): 407-11
Lawson DH, Tilstone WJ, Gray JM, Srivastava PK "Effect of furosemide on the pharmacokinetics of gentamicin in patients." J Clin Pharmacol 22 (1982): 254-8
"Product Information. Mycifradin (neomycin)." Emerson Laboratories, Texarkana, TX.
"Product Information. Nebcin (tobramycin)." Lilly, Eli and Company, Indianapolis, IN.
Johnson AH, Hamilton CH "Kanamycin ototoxicity: possible potentiation by other drugs." South Med J 63 (1970): 511-3
Kaka JS, Lyman C, Kilarski DJ "Tobramycin-furosemide interaction." Drug Intell Clin Pharm 18 (1984): 235-8
Mathog RH, Klein WJ "Ototoxicity of ethacrynic acid and aminoglycoside antibiotics in uremia." N Engl J Med 280 (1969): 1223-4
"Product Information. Arikayce (amikacin liposome)." Insmed Incorporated, Bridgewater, NJ.
Halstenson CE, Hirata CA, Heim-Duthoy KL, Abraham PA, Matzke GR "Effect of concomitant administration of piperacillin on the dispositions of netilmicin and tobramycin in patients with end-stage renal disease." Antimicrob Agents Chemother 34 (1990): 128-33
"Product Information. Garamycin (gentamicin)." Schering-Plough Corporation, Kenilworth, NJ.
Kaka JS, Lyman C, Kilarski DJ "Tobramycin-furosemide interaction." Drug Intell Clin Pharm 18 (1984): 235-8
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Weibert R, Keane W, Shapiro F "Carbenicillin inactivation of aminoglycosides in patients with severe renal failure." Trans Am Soc Artif Intern Organs 22 (1976): 439-43

Neomycin Oral Solution

Generic Name: neomycin

Brand name: Neo-Fradin, Neo-Tab, Mycifradin

Synonyms: Neomycin

What is Neomycin Oral Solution?

Plazomicin Intravenous

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: Plazomicin

What is Plazomicin Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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