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Neoral and Nicardipine Capsules

Determining the interaction of Neoral and Nicardipine Capsules and the possibility of their joint administration.

Check result:

Neoral <> Nicardipine Capsules

Relevance: 28.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with niCARdipine can cause damage to the kidneys or cause nerve loss. Tell your doctor if you experience dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage. Talk with your doctor if you develop fever, chills, body aches, flu symptoms, and severe pain in your upper stomach spreading to your back. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Nicardipine may increase blood cyclosporine levels. One study of 21 renal transplant recipients demonstrated a 19% to 214% increase in cyclosporine levels in patients concomitantly receiving oral nicardipine. The mechanism is not known, but may be decreased hepatic metabolism of cyclosporine. The risk of cyclosporine-induced nephrotoxicity and neurotoxicity may be increased.

MANAGEMENT: Cyclosporine levels and renal function, including serum creatinine, should be carefully monitored. The dosage should be adjusted as needed. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache. Amlodipine, isradipine and nitrendipine are not expected to affect cyclosporine to the same extent and may be considered as alternatives.

References

Guan D, Wang R, Lu J, Wang M, Xu C "Effects of nicardipine on blood cyclosporine levels in renal transplant patients." Transplant Proc 28 (1996): 1311-2
Martinez F, Pirson Y, Wallemacq P, et al "No clinically significant interaction between ciclosporin and isradipine." Nephron 59 (1991): 658-9
Tjia JF, Back DJ, Breckenridge AM "Calcium channel antagonists and cyclosporine metabolism: in vitro studies with human liver microsomes." Br J Clin Pharmacol 28 (1989): 362-5
Jacobs U, Klein B, Klehr HU "Cumulative side effects of cyclosporine and ca antagonists: hypergalactinemia, mastadenoma, and gynecomastia." Transplant Proc 26 (1994): 3122
Cantarovich M, Hiesse C, Lockiec F, Charpentier B, Fries D "Confirmation of the interaction between cyclosporine and the calcium channel blocker nicardipine in renal transplant patients." Clin Nephrol 28 (1987): 190-3
Sketris IS, Methot ME, Nicol D, Belitsky P, Knox MG "Effect of calcium-channel blockers on cyclosporine clearance and use in renal transplant patients." Ann Pharmacother 28 (1994): 1227-31
Deray G, Aupetit B, Martinez F, et al "Ciclosporin-nicardipine interaction." Am J Nephrol 9 (1989): 349

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

Nicardipine Capsules

Generic Name: nicardipine

Brand name: Cardene IV, Cardene SR, Cardene

Synonyms: NiCARdipine, Nicardipine (oral/injection)

What is Nicardipine Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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