Neoral and Noxafil (Posaconazole Injection)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cycloSPORINE together with posaconazole can increase the effects of cycloSPORINE. Talk with your doctor before using cycloSPORINE while you are using posaconazole. This can cause nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Posaconazole may significantly increase cyclosporine concentrations by inhibiting CYP450 3A4 metabolism. The risk of cyclosporine-related adverse effects may be increased. Serious adverse events including nephrotoxicity, leukoencephalopathy, and death were reported during clinical studies. Cyclosporine dosage reductions of up to 29% were required. Conversely, cyclosporine may increase plasma levels of posaconazole by inhibiting its clearance via P-glycoprotein-mediated efflux.

MANAGEMENT: Cycloporine dosage should be reduced to approximately 75% of the original dosage upon initiation of posaconazole treatment. Cyclosporine blood levels and renal function, including serum creatinine, should be carefully monitored during concomitant use and upon withdrawal of posaconazole. Patients should be advised to notify their physician if they experience symptoms that could indicate cyclosporine toxicity such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

Noxafil (Posaconazole Injection)

Generic Name: posaconazole

Brand name: Noxafil

Synonyms: Noxafil

What is Noxafil (Posaconazole Injection)?