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Neoral and Nydrazid

Determining the interaction of Neoral and Nydrazid and the possibility of their joint administration.

Check result:

Neoral <> Nydrazid

Relevance: 28.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using isoniazid together with cycloSPORINE may decrease the effects of cycloSPORINE. Contact your doctor if your condition changes. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Isoniazid may decrease serum cyclosporine concentrations. The mechanism is induction of hepatic CYP450 3A4 metabolism by isoniazid. Although cyclosporine and isoniazid have been safely used together in clinical trials with renal and heart transplant patients, individual cases of reduced cyclosporine blood levels have been reported.

MANAGEMENT: If these agents are used concomitantly, cyclosporine levels should be closely monitored. If an interaction is suspected, alterations in cyclosporine dosage may be necessary.

References

Sud K, Muthukumar T, Singh B, Garg SK, Kohli HS, Jha V, Gupta KL, Sakhuja V "Isoniazid does not affect bioavailability of cyclosporine in renal transplant recipients." Meth Find Exp Clin Pharmacol 22 (2000): 647-9
Zylberkatz E "Multiple drug interactions with cyclosporine in a heart transplant patient." Ann Pharmacother 29 (1995): 127-31
Kahan BD "The management of kidney transplant recipients treated with cyclosporine." Transplant Proc 15 (1983): 2641-8
Korner MM, Hirata N, Tenderich G, Minami K, Mannebach H, Kleesiek K, Korfer R "Tuberculosis in heart transplant recipients." Chest 111 (1997): 365-9
Kahan BD "The management of heart transplant recipients treated with cyclosporine." Transplant Proc 15 (1983): 2649-61
Langhoff E, Madsen S "Rapid metabolism of cyclosporin and prednisone in kidney transplant patients on tuberculostatic treatment." Lancet 2 (1983): 1303

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

Nydrazid

Generic Name: isoniazid

Brand name: Nydrazid

Synonyms: n.a.

What is Nydrazid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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