Neoral and Orlistat

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using cycloSPORINE together with orlistat. Using these medications together can make cycloSPORINE less effective. Given the risk of organ rejection associated with low cycloSPORINE levels, caution is advised if cycloSPORINE must be taken with orlistat. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or special test if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Limited clinical data suggest that orlistat may significantly reduce the oral bioavailability of cyclosporine. By partially inhibiting the absorption of dietary fat, orlistat may indirectly reduce the gastrointestinal absorption of cyclosporine, which is a highly lipid-soluble drug. There have been case reports of patients whose cyclosporine blood levels became subtherapeutic shortly following the initiation of orlistat therapy.

MANAGEMENT: Given the risk of organ rejection associated with inadequate drug levels, orlistat should preferably not be used in transplant patients treated with cyclosporine. If concomitant therapy is necessary, separating the doses by at least 2 hours may help minimize the potential for an interaction. Cyclosporine blood levels should be closely monitored and patients should be monitored for signs of rejection.

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

Orlistat

Generic Name: orlistat

Brand name: Alli, Xenical, Alli

Synonyms: n.a.

What is Orlistat?