Neoral and Pioglitazone and Glimepiride Tablets
Determining the interaction of Neoral and Pioglitazone and Glimepiride Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cycloSPORINE together with glimepiride may increase the effects of cycloSPORINE. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Glipizide may decrease the metabolism of cyclosporine. Cyclosporine levels may be increased by as much as 150%. It is not known whether other sulfonylureas will exhibit a similar interaction, although limited data do exist for glyburide. The proposed mechanism is inhibition of CYP450 hepatic metabolism.
MANAGEMENT: If a sulfonylurea is added or discontinued in a patient stabilized on cyclosporine, serum cyclosporine levels should be closely monitored. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.
- Islam SI, Masuda QN, Bolaji OO, Shaheen FM, Sheikh IA "Possible interaction between cyclosporine and glibenclamide in posttransplant diabetic patients." Ther Drug Monit 18 (1996): 624-6
- Chidester PD, Connito DJ "Interaction between glipizide and cyclosporine: report of two cases." Transplant Proc 25 (1993): 2136-7
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Neoral (Capsules, Modified)
Generic Name: glimepiride / pioglitazone
Brand name: Duetact
Synonyms: Glimepiride and pioglitazone, Pioglitazone and Glimepiride
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Neoral-Pioglitazone Hydrochloride
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- Neoral-Piperacillin
- Pioglitazone and Glimepiride Tablets-Neoral (Cyclosporine Capsules, Modified)
- Pioglitazone and Glimepiride Tablets-Neoral (Cyclosporine Oral Solution, Modified)
- Pioglitazone and Glimepiride Tablets-Neoral Oral
- Pioglitazone and Glimepiride Tablets-Neosar
- Pioglitazone and Glimepiride Tablets-Neosporin + Pain Relief Ointment
- Pioglitazone and Glimepiride Tablets-Neosporin AF Topical