Neoral and Promacta

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CycloSPORINE may decrease the blood levels of eltrombopag. You may need more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with cyclosporine may decrease eltrombopag exposure. The mechanism is unknown. Eltrombopag is an in vitro substrate and inhibitor of the breast cancer resistance protein (BCRP) efflux transporter, and cyclosporine also inhibits BCRP. In a drug interaction trial, a single dose of eltrombopag 50 mg with a single dose of cyclosporine 200 mg in healthy adults decreased eltrombopag Cmax and AUC by 25% and 18%, respectively. In the same trial, the same eltrombopag dose with a single dose of cyclosporine 600 mg in healthy adults decreased eltrombopag Cmax and AUC by 39% and 24%, respectively. However, the reduction in eltrombopag exposure was not considered clinically significant.

MANAGEMENT: It is generally recommended that the patient's platelet count be monitored at least weekly for 2 to 3 weeks when eltrombopag is coadministered with cyclosporine, and the eltrombopag dose adjusted as necessary.

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

Promacta

Generic Name: eltrombopag

Brand name: Promacta

Synonyms: n.a.

What is Promacta?