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Neoral and Prozac Weekly

Determining the interaction of Neoral and Prozac Weekly and the possibility of their joint administration.

Check result:

Neoral <> Prozac Weekly

Relevance: 28.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with FLUoxetine may alter the effects of cycloSPORINE. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: A case report has suggested that the addition or discontinuation of fluoxetine may increase or decrease cyclosporine levels, respectively. The proposed mechanism is inhibition of CYP450 3A4 hepatic microsomal enzymes.

MANAGEMENT: Until more information is available, cyclosporine levels and renal function, including serum creatinine, should be carefully monitored. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

References

Horton RC, Bonser RS "Interaction between cyclosporin and fluoxetine." BMJ 311 (1995): 422

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

Prozac Weekly

Generic Name: fluoxetine

Brand name: Prozac, Prozac Weekly, Sarafem, PROzac Pulvules, Rapiflux, Selfemra

Synonyms: n.a.

What is Prozac Weekly?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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