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Neoral (Cyclosporine Capsules, Modified) and Valcyte

Determining the interaction of Neoral (Cyclosporine Capsules, Modified) and Valcyte and the possibility of their joint administration.

Check result:

Neoral (Cyclosporine Capsules, Modified) <> Valcyte

Relevance: 03.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using cycloSPORINE together with valGANciclovir. Combining these medications may increase the risk of kidney damage and/or side effects that affect your bone marrow function, resulting in low numbers of different types of blood cells. You may be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Symptoms of kidney damage include swelling, weight gain, feeling short of breath, drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, pain in your lower back, and urinating more or less than usual or not at all. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special tests to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concurrent use of cyclosporine and ganciclovir or its prodrug, valganciclovir, may increase the risk of nephrotoxicity. Increased serum creatinine has been reported in transplant patients receiving intravenous ganciclovir and cyclosporine. Cases of eye movement disorders and ptosis have also been reported. Symptoms resolved within 1 to 2 days after discontinuation of both drugs and recurred in one patient upon rechallenge. The mechanism is unknown. In addition, use of cyclosporine and ganciclovir may increase the risk and severity of hematologic toxicity due to additive myelosuppressive effects.

MANAGEMENT: Close monitoring of renal function and for the development of severe hematologic adverse effects is recommended. In addition, consideration should be given to discontinuing one or both drugs if an eye movement disorder occurs.

References

Openshaw H, Slatkin NE, Smith E "Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir." Bone Marrow Transplant 19 (1997): 5035
"Product Information. Cytovene (ganciclovir)." Genentech, South San Francisco, CA.
"Product Information. Neoral Soft Gelatin Capsules (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0

Neoral (Cyclosporine Capsules, Modified)

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified), Neoral

What is Neoral (Cyclosporine Capsules, Modified)?

Valcyte

Generic Name: valganciclovir

Brand name: Valcyte

Synonyms: n.a.

What is Valcyte?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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