Drug search by name

Neosar and Tamoxifen Solution

Determining the interaction of Neosar and Tamoxifen Solution and the possibility of their joint administration.

Check result:

Neosar <> Tamoxifen Solution

Relevance: 23.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cyclophosphamide together with tamoxifen may increase the risk of dangerous blood clots, which can lead to serious conditions such as stroke, heart attack, heart failure, collapse, and kidney failure. You should seek immediate medical attention if you experience potential signs and symptoms of blood clots such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of tamoxifen with cyclophosphamide may increase the risk of thromboembolic complications. The mechanism of this interaction has not been delineated.

MANAGEMENT: Patients receiving tamoxifen with cyclophosphamide should receive clinical and laboratory monitoring for the development of thromboembolic events. It is not known whether prophylactic anticoagulation or antiplatelet therapy may lessen the risk of thromboembolic events; however, some authorities suggest that prophylactic antithrombotic measures should be considered if cyclophosphamide is given with tamoxifen. Patients should be advised to seek medical attention if they develop potential signs and symptoms of thromboembolism such as chest pain, shortness of breath, and pain or swelling in the arms or legs.

References

Pritchard KI, Paterson AH, Paul NA, Zee B, Fine S, Pater J "Increased thromboembolic complications with concurrent tamoxifen and chemotherapy in a randomized trial of adjuvant therapy for women with breast cancer. National Cancer Institute of Canada Clinical Trials Group Breast Cancer Site Group." J Clin Oncol 14 (1996): 2731-7
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Nolvadex (tamoxifen)." Zeneca Pharmaceuticals, Wilmington, DE.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Cytoxan (cyclophosphamide)." Bristol-Myers Squibb, Princeton, NJ.

Neosar

Generic Name: cyclophosphamide

Brand name: Cytoxan, Neosar, Cytoxan Lyophilized

Synonyms: n.a.

What is Neosar?

Tamoxifen Solution

Generic Name: tamoxifen

Brand name: Soltamox, Nolvadex

Synonyms: Tamoxifen

What is Tamoxifen Solution?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions