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Neut and Sinemet 100/10

Determining the interaction of Neut and Sinemet 100/10 and the possibility of their joint administration.

Check result:

Neut <> Sinemet 100/10

Relevance: 20.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Antacids and some oral aluminum, calcium, or magnesium containing preparations may increase the absorption of levodopa. The mechanisms may be related to increased gastric pH and/or decreased gastric emptying time, resulting in less gastric degradation of levodopa and more levodopa absorption from the small intestine. This effect may be beneficial in some patients, but also difficult to predict and monitor. For most patients, this interaction is not clinically significant and no specific intervention would be required. Dosing intervals could be spaced by at least 2 hours if it is preferred to avoid this interaction.

References

Rivera-Calimlim L, Dujovne CA, Morgan JP, Lasagna L, Bianchine JR "Absorption and metabolism of L-dopa by the human stomach." Eur J Clin Invest 1 (1971): 313-20
"Product Information. Sinemet (carbidopa-levodopa)." DuPont Pharmaceuticals, Wilmington, DE.
Fermaglich J, O'Dougherty DS "Effect of gastric motility on levodopa." Dis Nerv Syst 33 (1972): 624-5
Rivera-Calimlin L, Dujovne CA, Morgan JP, Lasagna L, Bianchine JR "L-dopa treatment failure: explanation and correction." Br Med J 4 (1970): 93-4

Neut

Generic Name: sodium bicarbonate

Brand name: Neut

Synonyms: Neut Injection

What is Neut?

Sinemet 100/10

Generic Name: carbidopa / levodopa

Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa

Synonyms: Carbidopa and levodopa, Carbidopa and Levodopa

What is Sinemet 100/10?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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