Neut and Sprycel

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Taking the dasatinib and sodium bicarbonate doses too close together may interfere with the absorption of dasatinib and reduce its effectiveness. To prevent or minimize the interaction, dasatinib and sodium bicarbonate dosing should be separated by at least two hours. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Nonclinical data indicate that the solubility of dasatinib is pH-dependent. Therefore, coadministration with antacids or agents with acid-neutralizing effects may reduce the oral bioavailability of dasatinib. In a pharmacokinetic study of 24 healthy subjects, administration of a 50 mg dose of dasatinib with 30 mL of aluminum hydroxide/magnesium hydroxide was associated with a 55% reduction in systemic exposure (AUC) and a 58% reduction in peak plasma concentration (Cmax) of dasatinib. However, when the same dose of aluminum hydroxide/magnesium hydroxide was administered two hours prior to the dasatinib dose, there was no significant change in dasatinib systemic exposure (AUC), and the dasatinib Cmax was increased 26%.

MANAGEMENT: Patients treated with dasatinib should avoid taking antacids or oral medications that contain antacids (e.g., didanosine buffered tablets or paediatric oral solution) for at least two hours before and two hours after administration of dasatinib.

Neut

Generic Name: sodium bicarbonate

Brand name: Neut

Synonyms: Neut Injection

What is Neut?

Sprycel

Generic Name: dasatinib

Brand name: Sprycel

Synonyms: n.a.

What is Sprycel?