Neut and Tasigna
Determining the interaction of Neut and Tasigna and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Taking the nilotinib and sodium bicarbonate doses too close together may interfere with the absorption of nilotinib and reduce its effectiveness. To prevent or minimize the interaction, nilotinib and sodium bicarbonate dosing should be separated by at least two hours. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Antacids significantly decrease the oral bioavailability of nilotinib. The mechanism is decreased solubility of nilotinib due to antacid-induced gastric pH increases. Nilotinib's solubility is pH-dependent and it is insoluble at a pH of 4.5 or higher.
MANAGEMENT: Patients treated with nilotinib should not take antacids or other agents with acid-neutralizing effects for at least 2 hours before or 2 hours after a nilotinib dose.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
Neut - Tasigna 
Neut - Tasigna 
Neut - Tasigna 
Neut - Tasigna 
Neut - Tasigna 
Neut - Tasigna 
Neut - Tasigna 
Neut - Tasigna 
Neut - Tasigna 
Neut - Tasigna 
Neut - Tasigna 
Neut - Tasigna