Nevirapine and Rapamune (Sirolimus Oral Solution)
Determining the interaction of Nevirapine and Rapamune (Sirolimus Oral Solution) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Nevirapine may reduce the blood levels of sirolimus in some patients, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of sirolimus and tacrolimus, both of which are primarily metabolized by the isoenzyme.
MANAGEMENT: Given the risk of organ rejection associated with inadequate immunosuppressant drug levels, caution is advised during concomitant therapy with CYP450 3A4 inducers. Sirolimus and tacrolimus blood levels should be checked frequently and the dosage adjusted accordingly whenever a CYP450 3A4 inducer is added to or withdrawn from therapy.
- "Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Rapamune (sirolimus)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
Generic Name: nevirapine
Brand name: Viramune, Viramune XR
Synonyms: n.a.
Generic Name: sirolimus
Brand name: Rapamune
Synonyms: Rapamune
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nevirapine-Rapamune (Sirolimus Tablets)
- Nevirapine-Rapamune Tablets
- Nevirapine-Rapiflux
- Nevirapine-Rapivab
- Nevirapine-Raptiva
- Nevirapine-Rasagiline
- Rapamune (Sirolimus Oral Solution)-Nevirapine Extended Release
- Rapamune (Sirolimus Oral Solution)-Nevirapine Extended-Release Tablets
- Rapamune (Sirolimus Oral Solution)-Nevirapine Oral Suspension
- Rapamune (Sirolimus Oral Solution)-Nevirapine Suspension
- Rapamune (Sirolimus Oral Solution)-Nevirapine Tablets
- Rapamune (Sirolimus Oral Solution)-New Day