Nevirapine Extended-Release Tablets and Tegretol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using carBAMazepine together with nevirapine may decrease the effects of both medications. Contact your doctor if your condition changes or if you experience seizures and other mental status changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of carbamazepine and nevirapine may result in decreased plasma concentrations of both drugs. Since both are substrates as well as inducers of CYP450 3A4, it is conceivable that each may increase metabolism of the other. However, data are limited. In four healthy, nonpregnant women, administration of a single 200 mg dose of nevirapine with 400 mg of carbamazepine resulted in a median decrease of 18.8 hours (range 15.6 to 38.0 hours) in the elimination half-life of nevirapine compared to administration alone. The decrease in nevirapine half-life led to faster undetectable nevirapine levels (median reduction in time to undetectable levels was 4 days; range 3.0 to 7.0 days), which the authors of the study suggest might reduce the risk of resistance development in pregnant women treated with single-dose nevirapine for prevention of vertical HIV transmission. However, the effect of the interaction on nevirapine during prolonged administration as part of highly active antiretroviral therapy (HAART) is unknown. In addition, the effect of nevirapine on carbamazepine pharmacokinetics has not been reported.

MANAGEMENT: Caution is advised during coadministration of carbamazepine and nevirapine. Pharmacologic effects and serum drug concentrations should be monitored more closely whenever either drug is added to or withdrawn from therapy.

Nevirapine Extended-Release Tablets

Generic Name: nevirapine

Brand name: Viramune, Viramune XR

Synonyms: Nevirapine

What is Nevirapine Extended-Release Tablets?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?