Nevirapine Extended-Release Tablets and Vfend

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using nevirapine together with voriconazole may decrease the effects of voriconazole. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with nevirapine may decrease the plasma concentrations of voriconazole. The mechanism is nevirapine induction of CYP450 3A4, the isoenzyme that is partially responsible for the metabolic clearance of voriconazole. Conversely, voriconazole may increase the plasma concentrations of nevirapine via inhibition of CYP450 3A4.

MANAGEMENT: Caution is advised if voriconazole and nevirapine must be used in combination. Patients should be monitored for potentially inadequate therapeutic response to voriconazole as well as nevirapine toxicity during coadministration of these drugs, and the dosage(s) adjusted accordingly.

Nevirapine Extended-Release Tablets

Generic Name: nevirapine

Brand name: Viramune, Viramune XR

Synonyms: Nevirapine

What is Nevirapine Extended-Release Tablets?

Vfend

Generic Name: voriconazole

Brand name: Vfend, Vfend

Synonyms: Vfend Injection

What is Vfend?