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Nevirapine Suspension and Rifabutin

Determining the interaction of Nevirapine Suspension and Rifabutin and the possibility of their joint administration.

Check result:

Nevirapine Suspension <> Rifabutin

Relevance: 26.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Rifabutin may modestly reduce plasma concentrations of nevirapine (by 16%). The mechanism is induction of CYP450 3A4 hepatic metabolism. Data are insufficient to determine the clinical significance or whether dosage adjustments are necessary. The manufacturer recommends that these drugs should be used in combination with caution and only if clearly indicated. Patients should be monitored for altered therapeutic effect.

References

"Notice to readers: updated guidelines for the use of rifabutin or rifampin for the treatment and prevention of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibiotrs." MMWR Morb Mortal Wkly Rep 49 (2000): 185-9
Burman WJ, Jones BE "Treatment of HIV-related tuberculosis in the era of effective antiretroviral therapy." Am J Respir Crit Care Med 164 (2001): 7-12
"Product Information. Viramune (nevirapine)." Boehringer-Ingelheim, Ridgefield, CT.
Back D, Gibbons S, Khoo S "Pharmacokinetic drug interactions with nevirapine." J Acquir Immune Defic Syndr 34 Suppl 1 (2003): S8-14

Nevirapine Suspension

Generic Name: nevirapine

Brand name: Viramune, Viramune XR

Synonyms: Nevirapine

What is Nevirapine Suspension?

Rifabutin

Generic Name: rifabutin

Brand name: Mycobutin

Synonyms: n.a.

What is Rifabutin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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