Nexiclon XR and Sinemet 100/25
Determining the interaction of Nexiclon XR and Sinemet 100/25 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cloNIDine together with levodopa can decrease the effects of levodopa. Contact your doctor if you experience a worsening of parkinson symptoms or an increase in rigidity and other movements. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited data suggest that clonidine may decrease the effectiveness of levodopa and piribedil by an unknown mechanism.
MANAGEMENT: During coadministration, the patient should be monitored for signs of increased rigidity and akinesia.
- Tarsy D, Parkes JD, Mardsen CD "Clonidine in Parkinson disease." Arch Neurol 32 (1975): 134-6
- Shoulson I, Chase TN "Clonidine and the anti-parkinsonian response to L-dopa or piribedil." Neuropharmacology 15 (1976): 25-7
Generic Name: clonidine
Brand name: Catapres, Catapres-TTS, Duraclon, Kapvay, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3
Synonyms: Nexiclon XR (Oral)
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: Carbidopa and levodopa, Carbidopa and Levodopa
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nexiclon XR-Sinemet 25-100
- Nexiclon XR-Sinemet 25-250
- Nexiclon XR-Sinemet 250/25
- Nexiclon XR-Sinemet CR
- Nexiclon XR-Sinemet CR 100/25
- Nexiclon XR-Sinemet CR 200/50
- Sinemet 100/25-Nexiclon XR Suspension
- Sinemet 100/25-Nexium
- Sinemet 100/25-Nexium (Esomeprazole Delayed-Release Capsules)
- Sinemet 100/25-Nexium (Esomeprazole Powder for Suspension)
- Sinemet 100/25-Nexium 24HR (Esomeprazole Delayed-Release Capsules)
- Sinemet 100/25-NexIUM 24HR (Esomeprazole Delayed-Release Tablets)