Nexium and Phenobarbital Oral Solution
Determining the interaction of Nexium and Phenobarbital Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 2C19 may theoretically increase the plasma concentrations of phenobarbital, which is a substrate of the isoenzyme. Some studies have reported an approximately 20% decrease in the total clearance of phenobarbital in individuals who are poor metabolizers of CYP450 2C19, although an interaction with specific CYP450 2C19 inhibitors has not been reported. Other studies have found no significant difference in the pharmacokinetics of phenobarbital amongst subjects with various CYP450 2C19 genotypes, which would suggest a minor role of CYP450 2C19 in the overall clearance of phenobarbital. No precautions appear to be necessary during coadministration of phenobarbital with CYP450 2C19 inhibitors. However, dosage adjustments may be necessary if an interaction is suspected.
- Klotz U "The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications." Clin Pharmacokinet 46 (2007): 271-9
Generic Name: esomeprazole
Brand name: Nexium, Esomeprazole Strontium, Nexium, NexIUM 24HR, Nexium IV
Synonyms: n.a.
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: Phenobarbital, PHENobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nexium-Phenobarbital Sodium
- Nexium-Phenobarbital Sodium Injection
- Nexium-Phenobarbital Tablets
- Nexium-Phenobarbital with Belladonna Alkaloids Elixir
- Nexium-Phenohytro
- Nexium-Phenohytro Elixir
- Phenobarbital Oral Solution-Nexium (Esomeprazole Delayed-Release Capsules)
- Phenobarbital Oral Solution-Nexium (Esomeprazole Powder for Suspension)
- Phenobarbital Oral Solution-Nexium 24HR (Esomeprazole Delayed-Release Capsules)
- Phenobarbital Oral Solution-NexIUM 24HR (Esomeprazole Delayed-Release Tablets)
- Phenobarbital Oral Solution-Nexium Capsules
- Phenobarbital Oral Solution-Nexium I.V.