NexIUM 24HR (Esomeprazole Delayed-Release Tablets) and Ponatinib
Determining the interaction of NexIUM 24HR (Esomeprazole Delayed-Release Tablets) and Ponatinib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with drugs that elevate the gastric pH such as proton pump inhibitors, H2-receptor antagonists, and antacids may decrease the oral bioavailability of ponatinib and reduce its concentrations in plasma. The aqueous solubility of ponatinib has been shown to be pH-dependent, with higher pH resulting in decreased solubility. However, in a drug interaction study in healthy volunteers, coadministration of ponatinib after multiple doses of lansoprazole resulted in a minor reduction in ponatinib Cmax but no change in overall systemic exposure (AUC) compared to ponatinib administered alone. Therefore, ponatinib may be coadministered with medicines that increase gastric pH without dose adjustment or separation of administration.
- "Product Information. Iclusig (ponatinib)." Ariad Pharmaceuticals Inc, Cambridge, MA.
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: esomeprazole
Brand name: NexIUM 24HR, Esomeprazole Strontium, Nexium, Nexium, Nexium IV
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- NexIUM 24HR (Esomeprazole Delayed-Release Tablets)-Ponstel
- NexIUM 24HR (Esomeprazole Delayed-Release Tablets)-Pontocaine
- NexIUM 24HR (Esomeprazole Delayed-Release Tablets)-Pontocaine HCl
- NexIUM 24HR (Esomeprazole Delayed-Release Tablets)-Porfimer
- NexIUM 24HR (Esomeprazole Delayed-Release Tablets)-Porfimer Intravenous
- NexIUM 24HR (Esomeprazole Delayed-Release Tablets)-Portia
- Ponatinib-Nexium Capsules
- Ponatinib-Nexium I.V.
- Ponatinib-Nexium I.V. Injection
- Ponatinib-Nexium Oral
- Ponatinib-Nexplanon
- Ponatinib-Next Choice