Nicardipine oral/injection and Phenobarbital Sodium Injection
Determining the interaction of Nicardipine oral/injection and Phenobarbital Sodium Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PHENobarbital may reduce the blood levels and effects of niCARdipine. Contact your doctor if your condition worsens or niCARdipine is no longer controlling your symptoms. Your doctor may be able to prescribe alternative treatments that do not interact, or you may need a dose adjustment or more frequent monitoring of your blood pressure and heart rate to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum concentrations and effects of these calcium channel blockers may be significantly decreased.
MANAGEMENT: If concurrent administration cannot be avoided, the patient should be closely monitored for changes in pharmacologic effects whenever a barbiturate is initiated, discontinued or its dosage adjusted. An increased dosage of the calcium channel blocker may be necessary.
- Koleva MR, Stoychev TS "Effect of nifedipine, verapamil and diltiazem on the enzyme-inducing activity of phenobarbital and beta-naphthoflavone." Gen Pharmacol 26 (1995): 225-8
- Hamann SR, Blouin RA, Chang SL, et al "Effects of hemodynamic changes on the elimination kinetics of verapamil and nifedipine." J Pharmacol Exp Ther 231 (1984): 301-5
- Schellens JH, Van Der Wart JH, Brugman M, Breimer D "Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design." J Pharmacol Exp Ther 249 (1989): 638-45
Generic Name: nicardipine
Brand name: Cardene IV, Cardene SR, Cardene
Synonyms: Nicardipine (oral/injection), NiCARdipine
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: Phenobarbital, PHENobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nicardipine oral/injection-Phenobarbital Tablets
- Nicardipine oral/injection-Phenobarbital with Belladonna Alkaloids Elixir
- Nicardipine oral/injection-Phenohytro
- Nicardipine oral/injection-Phenohytro Elixir
- Nicardipine oral/injection-Phenoxybenzamine
- Nicardipine oral/injection-Phenoxybenzamine Capsules
- Phenobarbital Sodium Injection-NicAzel Doxy Kit
- Phenobarbital Sodium Injection-NicAzel Forte
- Phenobarbital Sodium Injection-Niclosamide
- Phenobarbital Sodium Injection-Nicoderm
- Phenobarbital Sodium Injection-Nicoderm C-Q transdermal
- Phenobarbital Sodium Injection-Nicoderm CQ