Nicotine Oral, Transdermal and Varenicline

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using nicotine together with varenicline can cause an increase in side effects. Contact your doctor if you experience nausea, headache, vomiting, dizziness, and fatigue. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of varenicline and nicotine replacement therapy has been associated with increased adverse effects. In one study, a higher incidence of nausea, headache, vomiting, dizziness, dyspepsia, and fatigue was observed for the combination compared to transdermal nicotine replacement therapy alone. Eight of the 22 subjects (36%) treated with the combination prematurely discontinued treatment due to adverse events, compared to 1 of 17 (6%) of subjects treated with nicotine replacement therapy and placebo. Varenicline (1 mg orally twice a day) did not affect the pharmacokinetics of nicotine (21 mg/day transdermally) when coadministered for up to 12 days.

MANAGEMENT: The safety and efficacy of varenicline in combination with other smoking cessation therapies have not been established. Tolerability may be reduced if varenicline is coadministered with nicotine replacement therapy.

Nicotine Oral, Transdermal

Generic Name: nicotine

Brand name: Leader Nicotine Polacrilex, Nicorelief, Nicorette, Thrive, Commit, Habitrol, Nicoderm C-Q, Nicotine System Kit, Nicoderm CQ, Nicotrol Inhaler, Nicotrol NS

Synonyms: Nicotine Gum and Lozenges, Nicotine

What is Nicotine Oral, Transdermal?

Varenicline

Generic Name: varenicline

Brand name: Chantix, Chantix Starter Pack, Chantix Continuing Month

Synonyms: n.a.

What is Varenicline?