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Nicotrol Inhaler and Orphenadrine w/A.C.

Determining the interaction of Nicotrol Inhaler and Orphenadrine w/A.C. and the possibility of their joint administration.

Check result:

Nicotrol Inhaler <> Orphenadrine w/A.C.

Relevance: 10.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.

References

Yoovathaworn KC, Sriwatanakul K, Thithapandha A "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet 11 (1986): 71-6

Nicotrol Inhaler

Generic Name: nicotine

Brand name: Nicotrol Inhaler, Nicotrol NS, Commit, Leader Nicotine Polacrilex, Nicorelief, Nicorette, Thrive, Habitrol, Nicoderm C-Q, Nicotine System Kit, Nicoderm CQ

Synonyms: Nicotrol Inhaler (nasal, inhalation), Nicotrol Inhalant

What is Nicotrol Inhaler?

Orphenadrine w/A.C.

Generic Name: aspirin / caffeine / orphenadrine

Brand name: Norgesic Forte, Orphengesic Forte, Norgesic, Orphengesic

Synonyms: Aspirin, caffeine, and orphenadrine, Orphenadrine Aspirin Caffeine

What is Orphenadrine w/A.C.?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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