Nicotrol Inhaler and Zantac (Ranitidine Injection)
Determining the interaction of Nicotrol Inhaler and Zantac (Ranitidine Injection) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:H2 antagonists may reduce the clearance of nicotine. Cimetidine, 600 mg given twice a day for two days, reduced clearance of an intravenous nicotine dose by 30%. Ranitidine, 300 mg given twice a day for two days, reduced clearance by 10%. The clinical significance of this interaction is not known. Patients should be monitored for increased nicotine effects when using the patches or gum for smoking cessation and dosage adjustments should be made as appropriate.
- Bendayan R, Sullivan JT, Shaw C, Frecker RC, Sellers EM "Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans." Eur J Clin Pharmacol 38 (1990): 165-9
Generic Name: nicotine
Brand name: Nicotrol Inhaler, Nicotrol NS, Commit, Leader Nicotine Polacrilex, Nicorelief, Nicorette, Thrive, Habitrol, Nicoderm C-Q, Nicotine System Kit, Nicoderm CQ
Synonyms: Nicotrol Inhaler (nasal, inhalation), Nicotrol Inhalant
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Zantac
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nicotrol Inhaler-Zantac (Ranitidine Syrup)
- Nicotrol Inhaler-Zantac (Ranitidine Tablets and Capsules)
- Nicotrol Inhaler-Zantac Cool Mint
- Nicotrol Inhaler-Zantac Injection
- Nicotrol Inhaler-Zapzyt Cleansing Topical
- Nicotrol Inhaler-Zapzyt Topical
- Zantac (Ranitidine Injection)-Nicotrol Inhaler nasal, inhalation
- Zantac (Ranitidine Injection)-Nicotrol NS
- Zantac (Ranitidine Injection)-Nicotrol NS nasal, inhalation
- Zantac (Ranitidine Injection)-Nicotrol Oral, Transdermal
- Zantac (Ranitidine Injection)-Nidagel
- Zantac (Ranitidine Injection)-Nifediac CC