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Nifedical XL and Pioglitazone and Glimepiride Tablets

Determining the interaction of Nifedical XL and Pioglitazone and Glimepiride Tablets and the possibility of their joint administration.

Check result:

Nifedical XL <> Pioglitazone and Glimepiride Tablets

Relevance: 06.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

According to the pioglitazone labeling, coadministration of pioglitazone for 7 days with extended-release nifedipine 30 mg (brand not specified) orally once daily for 4 days to male and female volunteers resulted in slightly decreased bioavailability of nifedipine. The clinical significance of this finding is unknown. However, given the high variability of nifedipine pharmacokinetics, it may be appropriate to monitor patients for potentially diminished therapeutic effects of nifedipine when given with pioglitazone.

References

"Product Information. Actos (pioglitazone)" Takeda Pharmaceuticals America, Lincolnshire, IL.

Nifedical XL

Generic Name: nifedipine

Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat

Synonyms: Nifedical XL (Oral)

What is Nifedical XL?

Pioglitazone and Glimepiride Tablets

Generic Name: glimepiride / pioglitazone

Brand name: Duetact

Synonyms: Glimepiride and pioglitazone, Pioglitazone and Glimepiride

What is Pioglitazone and Glimepiride Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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