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Nifedical XL and Tibsovo

Determining the interaction of Nifedical XL and Tibsovo and the possibility of their joint administration.

Check result:

Nifedical XL <> Tibsovo

Relevance: 06.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with ivosidenib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. No pharmacokinetic data are available; however, ivosidenib induces its own metabolism via CYP450 3A4. MANAGEMENT: Concomitant use of ivosidenib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. If coadministration is required, patients should be monitored carefully for potential loss of therapeutic effects. References "Product Information. Tibsovo (ivosidenib)." Agios Pharmaceuticals, Cambridge, MA.

Professional:

GENERALLY AVOID: Coadministration with ivosidenib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. No pharmacokinetic data are available; however, ivosidenib induces its own metabolism via CYP450 3A4.

MANAGEMENT: Concomitant use of ivosidenib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. If coadministration is required, patients should be monitored carefully for potential loss of therapeutic effects.

References

"Product Information. Tibsovo (ivosidenib)." Agios Pharmaceuticals, Cambridge, MA.

Nifedical XL

Generic Name: nifedipine

Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat

Synonyms: Nifedical XL (Oral)

What is Nifedical XL?

Tibsovo

Generic Name: ivosidenib

Brand name: Tibsovo

Synonyms: n.a.

What is Tibsovo?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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