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Nifedical XL and Valproic Acid and Derivatives

Determining the interaction of Nifedical XL and Valproic Acid and Derivatives and the possibility of their joint administration.

Check result:

Nifedical XL <> Valproic Acid and Derivatives

Relevance: 06.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Valproic acid may increase the blood levels and effects of NIFEdipine. You may be more likely to experience serious side effects such as irregular heart rhythm, fluid retention, swelling, heart failure, and excessively low blood pressure. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek medical attention if you experience dizziness or fainting; sudden, unexplained weight gain; swelling of the hands, ankles, or feet; chest pain; or difficulty breathing during treatment with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Valproic acid and its derivatives may theoretically increase the effects of nifedipine by decreasing its first-pass metabolism and increasing bioavailability. The clinical significance is unknown.

MANAGEMENT: It is recommended to monitor blood pressure and consider dose reductions of nifedipine during concomitant therapy.

References

Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
"Product Information. Adalat (nifedipine)." Bayer, West Haven, CT.
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Nifedical XL

Generic Name: nifedipine

Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat

Synonyms: Nifedical XL (Oral)

What is Nifedical XL?

Valproic Acid and Derivatives

Generic Name: valproic acid

Brand name: Depakene, Depacon, Stavzor, Valproate Sodium

Synonyms: Valproic acid

What is Valproic Acid and Derivatives?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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