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Nifedipine and Quinidex Extentabs

Determining the interaction of Nifedipine and Quinidex Extentabs and the possibility of their joint administration.

Check result:

Nifedipine <> Quinidex Extentabs

Relevance: 16.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using quiNIDine together with NIFEdipine may alter the effects of both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, ringing in the ears, hearing loss, visual disturbances, dizziness, headache, confusion, low blood pressure, and swelling in your legs. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Some dihydropyridine calcium channel blockers may increase or decrease serum quinidine concentrations by an unknown mechanism. Data have been conflicting. No changes in quinidine concentrations have also been reported. Increased quinidine levels have been associated with QTc prolongation. In addition, quinidine may increase calcium channel blocker levels.

MANAGEMENT: It is recommended that the effectiveness of quinidine and the calcium channel blocker be monitored and that serum quinidine levels be checked when clinically appropriate. Patients should be advised to promptly report any early symptoms of quinidine toxicity (e.g., nausea, vomiting, diarrhea, tinnitus, hearing loss, visual disturbances, dizziness, headache, and confusion) or excessive calcium channel blockade (e.g., hypotension and lower extremity edema).

References

Bailey DG, Freeman DJ, Melendez LJ, Kreeft JH, Edgar B, Carruthers SG "Quinidine interaction with nifedipine and felodipine: pharmacokinetic and pharmacodynamic evaluation." Clin Pharmacol Ther 53 (1993): 354-9
Farringer JA, Green JA, O'Rourke RA, et al "Nifedipine-induced alterations in serum quinidine concentrations." Am Heart J 108 (1984): 1570-2
Green JA, Clementi WA, Porter C, Stigelman W "Nifedipine-quinidine interaction." Clin Pharm 2 (1983): 461-5
Munger MA, Jarvis RC, Nair R, et al "Elucidation of the nifedipine-quinidine interaction." Clin Pharmacol Ther 45 (1989): 411-6
Schellens JH, Ghabrial H, van der Wart HH, et al "Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans." Clin Pharmacol Ther 50 (1991): 520-8
Van Lith RM, Appleby DH "Quinidine-nifedipine interaction." Drug Intell Clin Pharm 19 (1985): 829-31

Nifedipine

Generic Name: nifedipine

Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat

Synonyms: NIFEdipine

What is Nifedipine?

Quinidex Extentabs

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quinidex Extentabs?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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