Nifedipine Capsules and Rifater
Determining the interaction of Nifedipine Capsules and Rifater and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:RifAMPin may significantly reduce the blood levels of NIFEdipine, which may make the medication ineffective or less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Potent inducers of CYP450 3A4 such as rifampin may significantly decrease the oral bioavailability of calcium channel blockers, the majority of which are primarily metabolized by the isoenzyme. Undetectable plasma levels have been reported for some calcium blockers when given orally.
MANAGEMENT: Concomitant use of oral calcium channel blockers with potent CYP450 3A4 inducers should generally be avoided. Some authorities consider the combination of nifedipine or nisoldipine with rifampin to be contraindicated.
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- Tada Y, Tsuda Y, Takeshi O, et al. "Case report: nifedipine-rifampicin interaction attenuates the effect on blood pressure in a patient with essential hypertension." Am J Med Sci 303 (1992): 25-7
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Generic Name: nifedipine
Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat
Synonyms: Nifedipine, NIFEdipine
Generic Name: isoniazid / pyrazinamide / rifampin
Brand name: Rifater
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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