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Nimbex and Prestalia

Determining the interaction of Nimbex and Prestalia and the possibility of their joint administration.

Check result:

Nimbex <> Prestalia

Relevance: 12.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cisatracurium together with amLODIPine can prolong the effects of cisatracurium. You should be closely monitored for prolong breathing cessation and respiratory paralysis after use of amLODIPine. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Some calcium channel blockers may enhance the neuromuscular blocking properties of nondepolarizing muscle relaxants. The mechanism is not known, but may involve blockage of calcium channels on skeletal muscle. Data are available for verapamil, diltiazem, nicardipine, atracurium, vecuronium, and pancuronium.

MANAGEMENT: Patients should be closely monitored for prolonged neuromuscular blockade. Reduced doses of muscle relaxants may be necessary. Profound neuromuscular blockade may be reversed by neostigmine or edrophonium.

References

Saitoh Y, Makita K, Tanaka H "Diltiazem and vecuronium: neuromuscular and cardiovascular effects." Can J Anaesth 44 (1997): 99
Wali FA "Interaction of verapamil with d-tubocurarine and cholinergic agonists at the avian neuromuscular junction." Acta Anaesthesiol Scand 31 (1987): 15-20
Carlos R, Erill S "Therapeutic Rounds." Clin Ther 9 (1986): 22-3
Sekerci S, Tulunay M "Interactions of calcium channel blockers with non-depolarising muscle relaxants in vitro." Anaesthesia 51 (1996): 140-4

Nimbex

Generic Name: cisatracurium

Brand name: Nimbex

Synonyms: n.a.

What is Nimbex?

Prestalia

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: n.a.

What is Prestalia?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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