Nintedanib Esylate and Phenytoin Extended-Release Capsules
Determining the interaction of Nintedanib Esylate and Phenytoin Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenytoin may significantly reduce the blood levels of nintedanib, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with inducers of P-glycoprotein (P-gp) and CYP450 3A4 may decrease the plasma concentrations of nintedanib, which is a substrate of the efflux transporter and a minor substrate of the isoenzyme. In a dedicated drug interaction study, administration of nintedanib with the potent P-gp and CYP450 3A4 inducer, rifampin, decreased nintedanib peak plasma concentration (Cmax) and systemic exposure (AUC) by 40% and 50%, respectively, compared to administration of nintedanib alone. No data are available for use with other, less potent inducers.
MANAGEMENT: Concomitant use of nintedanib with P-gp and CYP450 3A4 inducers should generally be avoided due to the potential for reduced efficacy.
- "Product Information. Ofev (nintedanib)." Boehringer Ingelheim, Ridgefield, CT.
Generic Name: nintedanib
Brand name: Ofev
Synonyms: Nintedanib
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nintedanib Esylate-Phenytoin Infatabs
- Nintedanib Esylate-Phenytoin injection
- Nintedanib Esylate-Phenytoin Intravenous
- Nintedanib Esylate-Phenytoin Oral Suspension
- Nintedanib Esylate-Phenytoin Sodium
- Nintedanib Esylate-Phenytoin Sodium, Prompt injection
- Phenytoin Extended-Release Capsules-Nipent
- Phenytoin Extended-Release Capsules-Niphanoid
- Phenytoin Extended-Release Capsules-Nipride RTU
- Phenytoin Extended-Release Capsules-Niraparib
- Phenytoin Extended-Release Capsules-Niraparib Tosylate
- Phenytoin Extended-Release Capsules-Niravam