Niraparib Tosylate and Verapamil oral/injection
Determining the interaction of Niraparib Tosylate and Verapamil oral/injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Verapamil may increase the blood levels and effects of niraparib. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with potent inhibitors of P-glycoprotein (P-gp) may increase the bioavailability of niraparib, which is a substrate of the efflux transporter. Increased levels of niraparib may lead to increased incidence of hematological toxicity (e.g., thrombocytopenia, anemia, neutropenia) and/or cardiovascular toxicity (e.g., hypertension, hypertensive crisis).
MANAGEMENT: Pharmacologic response to niraparib should be monitored more closely whenever a potent P-gp inhibitor is added to or withdrawn from therapy, and the niraparib dosage adjusted as necessary.
- "Product Information. Zejula (niraparib)." Tesaro Inc., Waltham, MA.
Generic Name: niraparib
Brand name: Zejula
Synonyms: Niraparib
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Niraparib Tosylate-Verapamil Sustained-Release Capsules
- Niraparib Tosylate-Verdeso
- Niraparib Tosylate-Verdrocet
- Niraparib Tosylate-Verelan
- Niraparib Tosylate-Verelan PM
- Niraparib Tosylate-Veripred 20
- Verapamil oral/injection-Niravam
- Verapamil oral/injection-Niravam Oral
- Verapamil oral/injection-Niron Komplete
- Verapamil oral/injection-Nisoldipine
- Verapamil oral/injection-Nitazoxanide
- Verapamil oral/injection-Nitazoxanide Suspension