Nitric Oxide and Onsolis

• Generic Name: nitric oxide
• Dosage Forms: n.a.
• Other Brand Names: Inomax

Used in conjunction with ventilatory support and other appropriate therapy to improve oxygenation and reduce the need for extracorporeal membrane oxygenation (ECMO) in term or near-term (>34 weeks of age) neonates with hypoxic respiratory failure and clinical or ECG evidence of pulmonary hypertension.

Most effective in patients with severe persistent pulmonary hypertension who have minimal underlying parenchymal lung disease (idiopathic persistent pulmonary hypertension).

Least effective in neonates with pulmonary hypoplasia (e.g., congenital diaphragmatic hernia).

Has been used with good results (i.e., decreased the incidence of severe intraventricular hemorrhage and periventricular leukomalacia) in premature neonates (<34 weeks’ gestation) who were undergoing mechanical ventilation for respiratory distress syndrome.

• Generic Name: fentanyl
• Dosage Forms: buccal soluble film
• Other Brand Names: Fentora, Onsolis, Abstral, Subsys, Actiq, Duragesic, Ionsys, Lazanda, Sublimaze

Onsolis buccal soluble film contains fentanyl, a narcotic (opioid) pain medicine.

Onsolis is used to treat "breakthrough" cancer pain that is not controlled by other medicines. Onsolis is taken together with other non-fentanyl narcotic pain medicine that is used around the clock. This medication is not for treating pain that is not cancer-related, such as general headaches or back pain.

Onsolis may also be used for purposes not listed in this medication guide.